Sedimentary rock is a lithology that is commonly encountered in mining practices. Their properties, especially the resistance against weathering, are often of critical importance to long-term engineering stability due to their ubiquitous existence on the earth’s crust. The weathering of rocks is a complex process that involves physical degradation, chemical and biological erosions. In this study, the impact of physical weathering on four common sedimentary rocks, namely sandstone, siltstone, limestone and shale, are simulated in the laboratoryoratory environment taking into consideration the impact of preservation condition, temperature and time. In order to optimise the design of the experiment, Taguchi’s design of experiment method is implemented based on the L16 orthogonal array and selected simulation conditions. The weight and dimension variation, fracture intensity, slake durability, and uniaxial strengths of specimens are then tested to quantify the impact of weathering under various conditions.