In a recent publication (Bueno and Lane, 2011) the authors presented the analysis of a consolidated dataset composed by 137 autogenous/semi-autogenous grinding (AG/SAG) mill pilot trials. By comparing the measured data against theoretical specific energy consumption, the analysis indicated which circuit configurations were more or less energy efficient. However, the analysis has also indicated that the energy efficiency of each of the types of circuits vary significantly.There are numerous factors that contribute to the variations of energy efficiency of AG/SAG mill-based circuits, such as feed size distribution, recycle ratios and ore characteristics. In view of this, the present work accesses these factors individually and discusses what may lead a particular circuit configuration to be more or less efficient in terms of energy and costs.CITATION:Bueno, M and Lane, G, 2012. Key drivers of energy and cost efficiency in autogenous/semi-autogenous grinding circuits, in Proceedings 11th AusIMM Mill Operators' Conference, pp 113-118 (The Australasian Institute of Mining and Metallurgy: Melbourne).