This paper describes a methodology for the design of mine pillars at the McArthur River Mine. The pillar strength is calculated using a method that accounts for confinement, pillar geometry and intact rock properties. The average pillar stress was calculated using in situ measurements of vertical stresses at shallow depth and the tributary area method in conjunction with numerical modelling. Observations of pillar behaviour indicate that an existing pillar stability graph may be slightly conservative and further adjustments for the local rockmass conditions are needed. The results to-date indicate that all mine pillars are stable for a range of mining geometries at McArthur River Mine.