Atmospheric air on a moisture free volume basis consists of approximately 21 per cent oxygen. The current minimum threshold for oxygen in Australia is 19.5 per cent. Atmospheric air generally will also contain water vapour and will also pick up further moisture as it flows around a mine ventilation network. This paper details the results of a study to determine how much oxygen depletion can occur due to the sole impact of increasing the moisture content of air and the potential impacts of this on ventilation system design. The study shows that the moisture content can have a significant impact on the oxygen concentration in mine air. The main factors controlling the impact are the barometric pressure, dry bulb temperature and relative humidity of the air.CITATION:Tuck, M A, 2015. What is the oxygen depletion potential of water vapour?, in Proceedings The Australian Mine Ventilation Conference, pp 173-176 (The Australasian Institute of Mining and Metallurgy: Melbourne).