This work presents design features of an innovative in-line mixing helical (coiled) reactor for flocculation and flotation as a solid-liquid separation process for suspended particles (including liquid droplets). The device has been named flocs generator reactor (FGR), a compact system whereby the flocculation of particles is assisted by the kinetic energy transfer from the hydraulic flow through the reactor and/or by the injection of microbubbles (30 - 70 m). The flow mixing presented a plug flow regime with a low dispersion degree, promoting the required hydrodynamic conditions to disperse the polymer flocculant (cationic polyacrylamide) and to generate strong' flocs of Fe(OH)3 or clays (as colloidal model systems) with aggregation using an anionic polymer, Al2(SO4)3 and poly aluminium chloride (PAC), and oil emulsions destabilisation with a high molecular weight cationic polymer. The solid-liquid separation of the flocs was then achieved either by settling or by flotation with microbubbles. This paper discusses advances in this new in-line flocculation-rapid flotation device to remove aerated aggregates', aggregates with entrained and entrapped bubbles. Studies were carried out with different models of FGRs (varying the length:volume ratio) and process efficiency (mainly kinetics) evaluated as a function of polymer concentration and some operating parameters, namely, feed flow-rate, air:solids ratio and residence time. Results showed that the aerated flocs are readily floated with rising rates in the order of 120 mh-1, values higher than those obtained for the settling of the non-aerated flocs (18 - 24 mh-1). The FGR requires short residence times and generates dense, well structured flocs (with a mass fractal dimension, dF of about three) which withstand high shear forces. Mechanisms involved appear to include small bubble formation and their rapid occlusion (entrapment) within flocs, nucleation of bubbles at floc/water interfaces, polymer coiling as a result of salting out' effects at the aqueous/air interface and plug flow type of mixing (flocculation). Successful examples of emulsified oil and solids removal from water are shown and because in all cases high efficiencies were obtained (>90 per cent removal). Due to the high process efficiency and high loading capacity shown, the FGR appears to have good potential as an in-line flotation-separator device in applications requiring high rate solid-liquid or liquid-liquid separations.