Kinetics of bubble-particle interaction, surface hydrophobicity and interfacial phenomena in sulfide mineral flotation are discussed in this paper. Results of the measurements of a bubble and mineral induction time (IT) and detachment force (DF), vacuum of bubble evolution (VE) and mineral floatability are discussed for pyrite, galena, chalcocite and chalcopyrite. Natural wetting and wetting induced by xanthates with different lengths of alkyl chains are examined. Experiments show the existence of several maxima of hydrophobicity on dependences of pH and electrochemical potential. These maxima are attributed as the reflection of mineral surface heterogeneity due to xanthate adsorption and the presence of cationic and anionic centres with uncompensated positive and negative charges. These charges can be neutralised by both regulation pH and applied potential. The aim of this paper is to evaluate a thickness of the rupturing film and to estimate how long the bubble-mineral interactions are according to the experimental values of IT, in order to develop a procedure for comparing of the results of DF and atomic force measurements in the same dimensionality, and to compare the results of the experimental studies on the wettability of sulfides with those predicted by the models of physics of capillarity.