Flotation is affected by several factors, part of which depends on the mineralogical characteristics of the ore and part on process variables. Sulfide Ni-Cu ores occur typically in mafic and ultramafic igneous rocks. Serpentine minerals are also common. As a consequence of metamorphosis, sulfides and secondary minerals may be finely disseminated in an altered ore matrix. The floatability of minerals depends also on process variables. Oxidation of sulfide particles, process iron and dissolved ions in process water affect the behaviour of sulfides. The effects of some essential factors on flotation of Ni-Cu ores are considered.