The flotation behaviour of the Hilton ore of Mount Isa Mines has been examined in the presence of two collectors (sodium ethyl xanthate (Ex) and sodium diisobutyldithiophosphinate (3418A)) over a range of flotation Eh values and collector additions. Tests were also conducted in the absence of collector to determine the relative contributions of natural and self-induced floatability of the major minerals in the feed. In these tests the influence of metabisulphite on the self-induced floatability of the minerals was also determined. Attention focussed on optimising the selectivity of galena flotation. It is shown that the Hilton ore sample contained lower levels of naturally hydrophobic iron sulphide minerals than are generally contained in the Mount Isa lead-zinc ore. Furthermore, the self-induced floatability of galena was less than that exhibited by the galena in the Mount Isa lead-zinc ore. Sodium metabisulphite (MBS) reduced the self-induced flotation of galena but had no effect on the natural floatability of the iron sulphide minerals.