Minerals are valuable resources and critical elements for a broad range of biological and technological applications, including technological developments to improve energy efficiency and the global movement to promote a low-carbon economy. However, in order to extract these critical metals, large amounts of waste and toxic chemicals are generated, as well as the use of high energy and large amounts of water consumption. Froth flotation is one of the most commonly used processes to separate and collect high-value minerals, but it still has some limitations, including low flotation efficiency performances using existing collectors and other reagents. Therefore, there is an urgent need to design and develop new metal-specific collectors to more efficiently separate and recover valuable minerals and to allow bulk water recovery from flocculated tailings. In this research, we propose to use our newly designed and synthesised novel collectors derived from a type of vitamin E (α-tocopherol), a relatively inexpensive and non-toxic natural molecule. As a potential collector-building block, α-tocopherol has a long hydrophobic carbon chain that facilitates the attachment to air bubbles during the froth flotation process. In addition, the phenol group of this molecule can be easily modified to incorporate various functional groups for targeting different types of minerals. Furthermore, α-tocopherol can be converted into a monomer for polymerisation by the reversible addition-fragmentation chain-transfer (RAFT) process, which can provide us with polymer based-collectors with high precision control of molecular weight and architecture. So far, small-scale qualitative experiments on α-tocopherol-based collectors have been performed with good results, which indicates the feasibility of these compounds as novel collectors for improved froth flotation processes.