Kaolinite is of very fine particle size in nature and thus its dispersion plays a key role in the successful removal of kaolinite in iron ore flotation and selective flocculation processes. As the most widely used dispersant in the world, sodium silicate has been used as a standard dispersant for kaolinite in the iron ore industry. However, the actual effect of sodium silicate on the colloid stability of kaolinite particles and its dispersion mechanism remain unknown in the literature. In this work, the dispersion effect and dispersion mechanisms of some common inorganic and organic dispersants, including sodium silicate, polyphosphate and a low molecular weight polyacrylic acid, on kaolinite particles were systematically investigated through electrophoretic mobility and colloidal stability studies over a wide pH range. It was found that sodium silicate-kaolinite interactions only take place in the neutral and acidic pH range, while polyacrylic acid and polyphosphate interact with kaolinite from pH 3 to 10.5. Consequently, sodium silicate only disperses kaolinite at neutral and acidic pH. In contrast, polyacrylic acid and polyphosphate disperse kaolinite from pH 3 to 10.5, with strong dispersion effect observed at neutral and acidic pH. In the iron ore industry, selective fl occulation and reverse cationic fl otation, the most widely used flotation route, are both conducted at pH 10 to 10.5. The results of the present study show that, at such high pH, polyacrylic acid and polyphosphate are more effective dispersants of kaolinite, in comparison with sodium silicate.