The Hamersley Basin of Western Australia, approximately 500 km long by 200 km wide, is recognised globally for its rich endowment of iron ore resources. Two types of bedded iron ore mineralisation are recognised: the Proterozoic hypogene martite-microplaty hematite ores; and the more recent Cenozoic supergene martite-goethite ores. Exploration strategies depend on the style of mineralisation being targeted; however, stratigraphy and structure are fundamental controls on both ore types. Therefore, the ability to visualise the 3D geology of the entire basin is critical for the understanding of iron ore occurrences and their relationship to ore genesis of bedded iron ore mineralisation. However, due to the large size of the basin, generating a 3D geological model of the regional stratigraphy and structure has not been possible, or prioritised, primarily due to software limitations. Recent advances in implicit automated geological modelling presents an ideal opportunity to develop a 3D model of the entire Hamersley Basin. The innovative Loop software was used to model open source geological data (ie geological mapping, outcrop orientation data, and fault data) sourced from the Geological Survey of Western Australia. In addition to generating a 3D geological model, information such as stratigraphic thickness and fault offset information was extracted using the map2loop module and demonstrated its application to exploration targeting. This study demonstrates how a basin-wide 3D geological model was used to conduct a regional structural analysis of the Hamersley Basin. The results of this study provide opportunities for other prospective regions to be rapidly modelled in order to enhance the understanding of the geology and improve exploration targeting.