In June 2012, Lucara Diamond Corporation officially commissioned its Karowe Diamond Mine in Letlhakane, Botswana. The processing plant circuit incorporates variable speed autogeneous milling, a first for African diamond processing - only previously practiced in Russia. The paper discusses the basis for the selection of milling against the more traditional circuits incorporating crushing and scrubbing. It covers early commissioning challenges of operating a mill in an alien environment' with no immediate reference plant to look up to for bench-marking.The paper describes how these challenges were overcome and learnings quickly incorporated into the mill operating philosophy for maximum diamond liberation and minimum product damage. The plant was commissioned in three months and by August 2012 the production ramp up had reached name-plate capacity. The feed to the mill has varied from highly weathered material to extremely hard kimberlite and the operating philosophy had to be optimised for the full range of ore types. While more work is required to stretch the mill operating envelope coupled with other circuit additions to improve liberation of fine diamonds at minimum capital expenditure, the mill has, to date, performed to its billing.CITATION:van Niekerk, L M, Ndlovu, G N and Sikwa, N A, 2013. Commissioning and operating an autogeneous mill at Karowe Diamond Mine, in Proceedings MetPlant 2013 , pp 215-228 (The Australasian Institute of Mining and Metallurgy: Melbourne).