To design and operate a successful mine the technical specialists must agree on what is ore, what is not ore, and how quickly the orebody is to be mined and processed. These seemingly simple questions defy easy analysis and can push mining engineers, geologists, metallurgists and others to the limit of their capabilities. The questions are rarely addressed adequately in feasibility studies or in operational planning. To optimise the mine and processing plant requires proper determination of cut-off grades or values, prediction of feed variability on an hourly, daily or longer basis, right-sizing the mining rate for optimum product quality, understanding the cost of capital and the expectations of investors, and many other considerations that involve geology, geotechnical engineering, mining, metallurgy, environmental effects and economics. This paper addresses the key matters that should be considered as inputs to the practical issues of metallurgical plant design and operation.CITATION:McCarthy, P L, 2015. Integrated mining and metallurgical planning and operation, in Proceedings MetPlant 2015, pp 35-45 (The Australasian Institute of Mining and Metallurgy: Melbourne).