Selective oxidation of minerals was used in this study to separate by flotation the copper sulphide minerals of chalcocite, covellite and chalcopyrite from the arsenic copper sulphide minerals of enargite and tennantite. It was found that a satisfactory separation of these minerals was only possible after selective oxidation of their surfaces in slightly acidic pH conditions, or after oxidation and selective dissolution of the surface oxidation products with a complexant in basic pH conditions.