Much of western New South Wales is characterised by an extensive regolith formed during more than 60 million years of exposure, weathering and erosion. This cover includes intensely weathered in situ regolith and superimposed transported materials of variable thickness, commonly in complex palaeochannel systems. Mineral exploration in this region has been considerably hampered by the cover, which can complicate or maskgeochemical anomalies and also obscure geophysical signatures. A detailed multi-disciplinary study of part of this region, centred on the Cobar-Girilambone area has demonstrated a methodology for exploring through this regolith. The approach involves regolith-landform mapping to establish the main landscape and palaeolandscape elements and to determine the nature and spatial occurrence of different regolith materials. By combining knowledge of the surface distribution of different regolith-landform units with available 3D information on the regolith and geophysical data it is possible to construct simplified derivative maps or exploration go' maps, which can be used to advise appropriate exploration strategies or help interpret acquired exploration data. This study has also established the major regolith controls on geochemical dispersion and determined key background element associations. These regolith-related element associations can result in highly variable background levels for many trace elements and need to be understood and factored into the analysis of geochemical data for different regolith sampling media. With better knowledge of the regolith it is possible to select the most appropriate exploration techniques and sampling media for a given area, as well as apply appropriate normalisation procedures to the acquired data. Exploration success can be greatly improved by using many existing techniques in regolith smart'ways.