Keno Hill, located north of Whitehorse, central Yukon, is Canadas second largest historic silver mining district, with over 214 million ounces (Moz) of silver produced at an average grade of 44 oz/t, and described as one of the richest Ag-Pb-Zn districts ever mined (Cathro, 2006). The area has limited outcrop and historic exploration was largely conducted by following vein hosting structures in underground workings, or geochemically through shallow surface RC type drilling through bouldery glacial overburden. Alexco acquired the property, including historic mining records containing over 740,000 m of drilling from 18,300 drill holes, in 2005. Since then multidiscipline district scale exploration including stratigraphic mapping, aerial geophysics, structural, petrological and geochemical study of the deposits, with 223,100 metres diamond drilling completed, has provided new understanding of the geologic framework and controls of mineralization. Between 2011 and 2013, Alexco produced 5.6 Moz silver from the underground Bellekeno Mine at an average grade of 725 g/t (23.1 oz/t) Ag, 9.5% Pb, 5.1% Zn, and has made two significant new discoveries at Flame & Moth and Bermingham. CITATION: McOnie, A and Iles, S, 2019. Geology and exploration of the Keno Hill Silver District, Yukon, Canada, in Proceedings PACRIM 2019, pp 310312 (The Australasian Institute of Mining and Metallurgy: Melbourne).