Recent advances in the disciplines involved in simulating large mining operations provide increasingly precise and accurate methods for the study of cave mechanics; however, in large regional-scale models, hydrological aspects are often neglected or studied independently from the mechanical problem. There exists a great demand for a unified approach to study and simulate both the mechanical and hydrological phenomena that allows for a more detailed understanding of the effects of groundwater flow, dewatering and the impact on block cave mining operations.This paper presents a numerical framework that combines three-dimensional regional-scale hydrological simulation techniques for groundwater flow, together with non-linear continuum-discontinuum rock mechanics models, provides such a unified modelling approach. The underlying simulation technique is based on a coupled parallel solution formulation adopting single-phase fluid flow formulations into a discontinuous, strain softening and dilatant finite element model. This approach is adopted for the presented case study of a realistic block caving example in a simplified unidirectional coupling formulation, to investigate the effects of the mechanical analysis on the hydrological response. Here, particular emphasis is on the non-linear coupling of the deformable and strain-softening solid skeleton and fluid phase; eg the change of hydraulic properties with evolution of damage in the rock mass and large-to-intermediate scale structures due to ongoing caving operations. The importance of discontinuum structures is discussed, as mining-induced fault reactivation significantly influences the hydrological response.CITATION:Flatten, A, Reusch, F and Beck, D, 2016. The application of hydromechanical mine-scale modelling for large block caving operations, in Proceedings Seventh International Conference and Exhibition on Mass Mining (MassMin 2016), pp 341-348 (The Australasian Institute of Mining and Metallurgy: Melbourne).