An extensive study was carried out to evaluate the performance of Outokumpu OK50, OK38 and Maxwell MX14 cells at Cominco's Red Dog flotation concentrator in Alaska. Tests were conducted by varying operating conditions of the cells installed in different circuits in the plant. The hydrodynamic and gas dispersion properties were measured and the metallurgical performance of the cells was evaluated for each condition used in the tests. This paper highlights the importance of superficial gas velocity, bubble surface area flux, gas hold-up, power consumption, residence time distribution and froth flow behaviour in optimising cell performance. The findings of these tests provide valuable insights into selection of the best cell operating conditions to optimise circuit performance.