During the development of the Neves-Corvo Underground Copper Mine, since 1981, inflow of water has been encountered in the mine workings, which consist of a ramp from surface 5 km long, a shaft 575 m deep and access crosscuts through the massive sulphide orebodies of Neves, Corvo and Graga, which are three of the four known deposits up today. Mine-hydrological studies have established the main characteristics of the hydrological system and its evolution in space and time. In a geological setting of low permeability rocks of Paleozoic age, tectonically affected by thrusts and faults, this has involved consideration of the relation with surface and ground water as a result of mine dewatering processes. The hydrological systems are described and summarized in this paper together with the techniques employed to study their origin and evolution, namely hydrochemistry, thermometry, piezometry and isotopic tracers.