This paper outlines the processes involved in acid generation from sulphides and the key factors in identifying and predicting time dependent changes in the nature of acid mine drainage (AMD). The initial characteristics of mine water; whether drainage from exposed mining faces, runoff and seepage from waste dumps or seepage from process tailings; do not necessarily reflect the long term potential for AMD. The ultimate quality of mine drainage is a function of the interaction of many chemical, physical, biological and engineering (operational) factors. Techniques are available that can predict the qualitative nature of acid generation and mine drainage quality but accurate quantitative predictions are essentially impossible at the present time. As more and more mining operations exploit sulphide ore, the AMD and acid waste issue will become a. far greater concern. The significance of time dependent factors in the production of acid mine drainage-.is not just restricted to particuL.ar mine sites but needs to be recognised by the mining industry as a whole.