In epithennal deposits changes in the character of mineralization in depth and time are conspicuous and abrupt at the interface between supergene and hypogene zones. As the reaction zone migrates downward as a consequence of surface erosion, previously deposited minerals are placed in unstable chemical enviromments and dissolved. This reaction takes place at the base of the epithermal precious metal zone. Examples at Cerro de Pasco, and Casapalca, Peru; Carlin, Nevada; and porphyry copper-gold deposits are cited.