A model based on non-steady state has been developed for dissolution and diffusion in porous ore particles. Results from the particular model have been incorporated, as a rate term, into a global, heap-scale model based on a plug flow reactor at unsteady state. The global model can be used to consider leaching by aqueous-phase reagents in equilibrium with a gas- phase component, such as oxygen gas, as well as strictly aqueous-phase reagents, such as cyanide. The flexibility of the model even allows predic- tion of the outcomes of using reagent sideflow injection in large heaps. Data from column leaching tests are compared to the model, and their relationship is discussed.