This paper proposes a new idea of disintegrating mode (division into simpler sub-problems) for complex problems, and based on -it, a study of the structure and the design of a knowledge base and inference engine for layout design of mineral concentrator expert systems. There is also a study of the formalisation method for describing the layout picture, and the work derived therefore found a formalisation method for expressing the knowledge and experience of layout design. There is also a study of the general characteristics of layout design knowledge.