The Copper Concentrator at Mount Isa Mines Limited treats on average 18 000 tonnes/day of chalcopyrite ore containing typically three per cent copper. The main gangue minerals are iron sulphides (-13 per cent) and non sulphide gangue (-78 per cent). In August, 1991, the comminution flowsheet was changed from a conventional circuit (crusher/rod mill/two stage ball milling) to a modem circuit (fully autogenous grinding/one stage ball milling). The 80 per cent passing size of the flotation feed with the conventional circuit was 125 microns. The Copper Concentrator has two parallel grinding lines, two roughing and scavenging flotation lines, and common cleaning, recleaning and retreatment sections. During the first six weeks of the installation phase, one of the two flotation lines was fed by the conventional grinding circuit and the other by the autogenous grinding circuit. Data from parallel surveys and historical data are used to analyse the rougher/scavenger flotation performance before and after the change. The solid and mineral distributions of the flotation feed, the pulp chemistry and the reagent requirements are compared. The mineral liberation before and after the installation of autogenous grinding is compared on a sized basis using data from the 14 consecutive months before, and the seven months after the change. Liberation was measured using the QEM*SEM(*) instrument. The overall effect of the new grinding circuit on the plant metallurgy is also assessed using the copper recovery values, the dilution of the final concentrate and the distribution of copper losses in the final tailings. (*) Quantitative Evaluation of Materials by Scanning Electron Microscopy