In this paper the reactions which may lead to particle hydrophobicity/hydrophilicity as a function of grinding environment-are reviewed. The results of pulp chemical investigations related to a Cu-Pb-Zn ore on a pilot plant scale and laboratory tests with a Pb-Zn ore to evaluate the effect of some inhibitors on grinding/flotation are presented. The flotation recoveries of the ores treated by conventional and autogenous grinding methods show only a marginal difference and the results favour autogenous grinding. Iron originating from several sources manifests in the form of insoluble hydroxy complexes in the pulps. Such metal hydroxy complexes are hydrophilic and coat the mineral surfaces indiscriminately. On the other hand, selectivity is a problem for pulps ground by autogenous milling. Some corrosion inhibitors used in the laboratory grinding/flotation tests on a Pb-Zn ore showed maximum reduction in the wear of the grinding media ranging from 25 - 36 per cent, depending on the type and concentration of the inhibitor.