Adsorption tests have been carried out to elucidate the interaction mechanism between dextrin and sulphide minerals. Sulphides such as galena and heazlewoodite exhibit high affinity adsorption over the pH range that coincides with the iep of lead and nickel hydroxides, and is suggestive of chemical interaction. The adsorption behaviour with respect to the sulphides of copper is of the low affinity type, and follows a different pattern. The adsorption studies on graphite, support the chemical interaction mechanism, with the metallic impurities serving as adsorption centres. In conformity with the proposed mechanism selective separation of galena from chalcopyrite and heazlewoodite from chalcocite has been Achieved.