Different conventional and non-conventional flowsheet configurations were examined for the treatment of a number of refractory lead-zinc and copper-lead-zinc ores containing carbonaceous pyrite, flotable non sulphide gangue and pre-activated zinc. The flowsheet configuration for the processing of complex massive sulphide ores has a remarkable effect on the overall metallurgical results. Conventional sequential flowsheets, with circulation of intermediate products for both lead-zinc and copper-lead-zinc ores, gave poor metallurgical results and often saleable concentrates were difficult to produce. The concept of semi-bulk flotation and double bulk flotation with coarser grinding of the ore, followed by single or double-stage regrinding and sequential flotation was established to be most effective in achieving optimum metallurgical results. This flowsheet design gave superior results as compared to the conventional sequential flowsheet, and resulted in a lower reagent consumption, a significant reduction in the circulation load of intermediate products, and improvement in the rate of flotation of valuable minerals. Thus, optimum flotation conditions were provided for different products within the flowsheet.